Changes in Cathepsin D Activity in the Tail of Rana catesbeiana Larvae during Spontaneous Metamorphosis

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概要

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• Catheptic activity, measured as hydrolysis of hemoglobin at pH 2.9 and attributed mainly to cathepsin D activity, was measured in the homogenate and subcellular fractions of the tadpole tail of bullfrog, Rana catesbeiana at four stages of spontaneous metamorphosis. The specific activity of the homogenate remarkably increased during tail regression, especially at the final stage (stage IV) with a 22.4-fold increase. The four fractions obtained by differential centrifugation showed the same change patterns as the homogenate. Tail cathepsin D was localized in the cytoplasmic particle fraction, but solubilization of the enzyme seemed to occur at the final stage. It was concluded that cathepsin D contributes to the protein degradation occurring in Rana catesbeiana tadpole tail during spontaneous metamorphosis.

• 社団法人日本動物学会の論文
• 1979-06-25

著者

• Horiuchi Shiro

  Life Science Institute Sophia University

• Sakai Junko

  Department Of Chemistry

関連論文

• Changes in Cathepsin D Activity in the Tail of Rana catesbeiana Larvae during Spontaneous Metamorphosis
• Some Aspects of the Shortening of the Small Intestine in Rana catesbeiana Larvae during Metamorphosis

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