エストロジェンによって引き起こされたマウスの凝固腺上皮における化生 : II. エストロジェン処理停止後の化生上皮における組織学的変化と分裂活性に及ぼすアンドロジェンの影響

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Histological changes and development of the mitotic activity following androgen treatment has been studied in metaplastic epithelium of mouse coagulating glands (CGs), which was produced by successive injections of 4μg estradiol benzoate (EB) for 30 days. In mice sacrificed one day after the last injection of EB (day 1), CGs showed a marked squamous metaplasia (Gr. 1, Fig. 1). The mitotic activity in the basal layer of these epithelia was significantly higher in the proximal portion of the glands than in the distal portion. In mice treated with 2.5mg testosterone propionate (TP) once on day 1 and killed next day (Gr. 2), however, the most active epithelial proliferation was observed in the basal layer at the distal portion of the gland (Fig. 2). The mitotic activity of the epithelium reached a peak on day 3 (see Fig. 9). In mice injected with TP 4 times and autopsied on day 5, transformation from squamous to stratified epithelium consisting of cuboidal and/or columnar cells (Fig. 6) was notable at the distal portion, although the squamous stratified structure still existed at the proximal portion of these animals. Furthermore, the simple columnar epithelium appeared sporadically in the stratified or pseudostratified epithelial linings of the distal portion in TP-treated mice, which were sacrificed on day 7 (Fig. 7). Ten days after TP treatment had been started, the most portions of the gland became lined with a well differentiated single layer of columnar cells. These results suggest that the distal portion of the CGs is the most sensitive area to androgen and the proximal portion is presumably the area most sensitive to estrogen. Therefore, it can be assumed that the epithelium of CGs consists of cell populations which have different nature in response to sex steroid hormones.
1973-09-25

エストロジェンによって引き起こされたマウスの凝固腺上皮における化生 : II. エストロジェン処理停止後の化生上皮における組織学的変化と分裂活性に及ぼすアンドロジェンの影響

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