マイクロフォン電位におよぼす内耳外リンパ液交換の影響

概要

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In order to find the site of major oxygen supply to the hair cells, effects of changing perilymph for Ringer's solution, glucose-glucose oxidase solution or DNP solution on microphonic potential was studied in the guinea pig. Microphonic potential decreased approximately to 50% of its original amplitude when glucose-glucose oxidase mixture was perfused into scala tympani of the basal turn. The recorded value was never less than 35% of the original amplitude. When nitrogen was applied to the animal through trachea after microphonic potential had decreased to 50% of its original amplitude, further 30% decrease of the potential was recorded. When nitrogen was applied for only 1 minute to the animal treated with glucose-glucose oxidase mixture, it took about 6 minutes for microphonic potential to recover to the 50% level of its original amplitude. With perfusion of DNP solution into the scala tympani, microphonic potential decreased to 20% of its original amplitude. When nitrogen was applied to the animal treated with DNP solution, no further decrease was observed. From these results, it is concluded that the major oxygen supply to the hair cell is mainly from perilymph; in addition to this, certain other factor should be taken into consideration such as blood vessels in stria vascularis.
社団法人日本動物学会の論文
1970-07-15