Hundredth Anniversary of the "Synapse" : II. Study of the Cholinergic Synapse

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概要

• 論文の詳細を見る

• Major contributions to the research on the cholinergic synapse in the last five decades was described. The original notion of active zone, composed of a presynaptic dense projection and associated synaptic vesicles, was analyzed in order to underline its functional meaning in synaptic transmission. An overview was done on the findings made on acetylcholine release (ultrastructural aspect, cytochemistry, non-vesicular hypothesis and mediatophore), acetylcholinesterase (ultrastructural localization, discovery of molecular polymorphism) and acetylcholine receptor (characterization, purification). The structural base of the smallest functional unit in a synapse was attributed to a single synaptic vesicle of active zone and corresponding area of synaptic cleft and postsynaptic membrane interacting with the neurotransmitter released from the vesicle.

• 社団法人日本動物学会の論文

著者

• Tsuji Shigeru

  Institut Des Neurosciences (cnrs Ura 1488) Universite Pierre Et Marie Curie

• ANGLADE Philippe

  Institut des Neurosciences (CNRS URA 1488), Université Paris VI

• Anglade Philippe

  Institut Des Neurosciences (cnrs Ura 1488) Universite Pierre Et Marie Curie

関連論文

• Acetylcholinesterase activity in the frog neuromuscular junction observed at electron microscopic level after histoenzymatic reaction
• Capture of [3H]-choline by Fibrocytes of Frog Motor Endplate Region
• Hundredth Anniversary of the "Synapse" : I. A Short History of the Milestones in Synapse Research
• Hundredth Anniversary of the "Synapse" : II. Study of the Cholinergic Synapse

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