Intracellular Alkalinization Enhances Inward Rectifier K^+ Current in Retinal Horizontal Cells of Catfish
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概要
- 論文の詳細を見る
Isolated cone-driven horizontal cells dissociated from catfish retina were voltage-clamped using the whole-cell patch-clamp technique. The effects of acidification and alkalinization on an anomalous type, inwardly-rectifying K^+ current (IRK^+) were investigated. The magnitude of IRK^+ was enhanced by raising the intracellular pH above 7.4, however, in contrast, intracellular acidification had little effect on this current. The range over which intracellular pH ([pH]_i) modulates IRK^+ is different from that for modulation of a sustained high-voltage activated calcium current in these same cells and also for proton-sensitive, inward rectifier currents in starfish oocytes, skeletal muscle and heart myocytes.
- 社団法人日本動物学会の論文
- 1995-02-15
著者
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Copenhagen David
Departments Of Ophthalmology And Physiology School Of Medicine University Of California San Francisc
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Takahashi Kyoh-ichi
Department Of Physiology Keio University School Of Medicine:departments Of Ophthalmology And Physiol
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Copenhagen R.
Departments Of Ophthalmology And Physiology University Of California School Of Medicine
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