Evidence for Non-steroidal Gonadal Regulator(s) of Gonadotropin Release in the Goldfish, Carassius auratus

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In mammals, it is well documented that in addition to steroidal hormones, gonads also produce a variety of non-steroidal proteins and peptides that can feed back to regulate pituitary gonadotropin secretion. The best studied among these non-steroidal substances are inhibin and activin. The present study demonstrates that in sharp contrast to mammalian gonadal extracts which usually have inhibitory effects on mammalian gonadotropin secretion due to inhibin, the aqueous goldfish gonadal extracts stimulate pituitary gonadotropin-II (GTH-II) release in goldfish. Interestingly, the actions of the goldfish gonadal extracts are similar to our previously reported effects of porcine follicular fluid on goldfish GTH-II release. The stimulatory activities of goldfish ovarian extracts and the pituitary resopnsiveness to this stimulation fluctuate dramatically with the ovarian development. The results presented in this paper support our previous findings that porcine inhibin and activin stimulate goldfish gonadotropin release and the immunoreactive inhibin and activin subunits are present in the goldfish gonads.
社団法人日本動物学会の論文
1994-10-15