Endocrine Control of Cartilage Growth in Coho Salmon : GH Influence in Vivo on the Response to IGF-I in Vitro

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概要

• 論文の詳細を見る

• Ceratobranchial cartilages from coho salmon (Oncorhynchus kisutch) parr, injected with growth hormone (GH) at 4μg/g body weight or with saline, were sampled monthly from February to July. Thymidine and sulfate uptakes by cartilages were determined as measures of DNA and chondroitin sulfate synthesis, respectively. Cartilages were incubated with IGF-I at 0. 01, 0. 1 and 1μg/ml to examine the in vitro response to this hormone. GH injection increased cartilage thymidine and sulfate uptakes at least four-fold in all experiments. IGF-I treatment in vitro further increased sulfate but not thymidine uptake in cartilages from GH-injected coho and increased uptake of both in cartilages from saline-treated coho. However, the IGF-stimulated uptakes were still significantly below the uptakes in cartilages from GH-injected coho. The dual effector hypothesis of GH action [12] in mammals is supported at least in part in teleost fishes by the observation that addition of IGF-I in vitro was not equivalent to injection of GH in vivo.

• 社団法人日本動物学会の論文
• 1994-04-15

著者

• Stephen D.

  Department Of Integrative Biology Bodega Marine Laboratory And Cancer Research Laboratory University

• Bern A.

  Department Of Integrative Biology Bodega Marine Laboratory And Cancer Research Laboratory University

• Madsen S

  Odense Univ. Odense Dnk

• Tsai I.

  Department of Integrative Biology, Bodega Marine Laboratory and Cancer Research Laboratory, Universi

• Madsen S.

  Department of Integrative Biology, Bodega Marine Laboratory and Cancer Research Laboratory, Universi

• Tsai I.

  Department Of Integrative Biology Bodega Marine Laboratory And Cancer Research Laboratory University

• Tsai Peter

  Department of Integrative Biology, Bodega Marine Laboratory and Cancer Research Laboratory, University of California

関連論文

• Endocrine Control of Cartilage Growth in Coho Salmon : GH Influence in Vivo on the Response to IGF-I in Vitro
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