Strictly Thymus-dependent Tolerance Induction in Immunologically Competent Xenopus Larvae
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概要
- 論文の詳細を見る
Larvae of J strain South African clawed frog Xenopus laevis (MHC haplotype ; JJ) can easily be rendered tolerant, during metamorphosis, of semixenogeneic adult skin grafts from interspecific hybrid (JB) made between JJ and X. borealis (BB). If larvae were thymectomized several days before, at the same time as, or within 1 week after the skin grafting, tolerance was no longer induced. Tolerance induction was restored by grafting late larval or adult thymuses before or within 1 week after skin grafting. Early larval thymuses were ineffective for this restoration. Overallresults indicate that the tolerance induced during metamorphosis is ascribable to a suppression exerted on a competent immune system in the presence of differentiated thymus.
- 社団法人日本動物学会の論文
- 1993-10-15
著者
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Tochinai Shin
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Tochinai Shin
Division Of Biological Science Faculty Of Science Hokkaido University
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