Acetylcholine Stimulates the Inhibited Acetylcholinesterase Activity in the Brain of a Snakehead, Channa punctatus

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概要

• 論文の詳細を見る

• Administration of Lomustine, a nitrosourea drug, at a dose of 2 mg/fish/day for 3 days significantly inhibited (P<0.01) brain acetylcholinesterase (AChE) activity of Channa punctatus, a snakehead fish. This inhibition was removed by acetylcholine (ACh)(1.8 mg/fish/day). Interestingly, ACh administration alone greatly stimulated (58%) AChE activity. In vitro incubation of fish brain slice with varied concentrations of Actinomycin-D (3.5×10^<-5>M, 3.5×10^<-6>M and 3.5×10^<-7>M) inhibited AChE in a dose dependent manner which was also reversed by ACh. Monitoring of protein synthesis in the brain slice indicated that the inhibitory effect of Actinomycin-D could be effectively overcome by ACh. ACh stimulated ^<14>C-leucine incorporation into fish brain protein which was inhibited by Actinomycin-D. Findings indicate a correlation between ACh stimulation of AChE activity and increased incorporation of ^<14>C-leucine into brain protein.

• 社団法人日本動物学会の論文
• 1993-08-16

著者

• Bhattacharya Shelley

  Environmental Toxicology Laboratory Department Of Zoology Visva-bharati University

• Ghosh Probodh

  Environmental Toxicology Laboratory Visva-bharati University

• Bhattachrya Samir

  Endocrinology Laboratory, Development of Zoology, Visva-Bharati University

• Bhattachrya Samir

  Endocrinology Laboratory Development Of Zoology Visva-bharati University

• Bhattacharya Samir

  Endocrinology Laboratory, Development of Zoology, Visva-Bharati University

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• Acetylcholine Stimulates the Inhibited Acetylcholinesterase Activity in the Brain of a Snakehead, Channa punctatus

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