Effect of the Oesophageal Mesenchyme on the Differentiation of the Digestive-tract Endoderm of the Chick Embryo

概要

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The endoderm of various regions of the digestive tract of 6-day chick embryos was cultured in vitro in recombination with the oesophageal or other digestive-tract mesenchymes of 6-day chick embryos, and the differentiation of the epithelium was examined with attention given to the appearance of the stratified squamous epithelium characteristic of the mature oesophageal epithelium. The oesophageal endoderm developed stratified squamous epithelium in high frequency in the presence of the oesophageal mesenchyme, but in low frequency when recombined with the other mesenchymes, which suggested the supporting action of the oesophageal mesenchyme on the proper differentiation of the oesophageal endoderm. Among the other endoderms of digestive tract, only the proventricular endoderm developed stratified squamous epithelium, when cultured in recombination with the oesophageal mesenchyme. The squamous cells of this epithelium contained numerous tonofilaments as those of the stratified squamous epithelium of the intact oesophagus. The ability to elicit stratified squamous epithelium in the proventricular endoderm was shown to be confined to the oesophageal mesenchyme. Thus, the oesophageal mesenchyme was likely to induce oesophagus-type differentiation at least in the proventricular endoderm.
社団法人日本動物学会の論文
1993-06-15