Prostaglandins and Sex Steroids from Reptilian (Podarcis sicula sicula) Ovarian Follicles at Different Developmental Stages

概要

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Prostaglandin F_<2α> (PGF_<2α>), prostaglandin E_2 (PGE_2), progesterone, androgens, and estradiol-17βin vitro basal release by follicles of the oviparous lizard, Podarcis s. sicula was studied ; in addition , the in vitro effect of PGF_<2α> and PGE_2 on sex steroid release was evaluated. Follicles were divided according to the different vitellogenic developmental stages : pre-vitellogenic, early-vitellogenic, mid-vitellogenic and fully-grown. PGF_<2α>and progesterone basal release was highest in fully-grown follicles ; PGE_2 and estradiol basal release was highest in early-vitellogenic follicles ; androgens basal release was detectable in mid-vitellogenic and fully-grown vitellogenic follicles only. PGF_<2α> increased progesterone release by fully-grown follicles ; PGE_2 increased estradiol release by all follicle types, except by early-vitellogenic ones. The present data suggest that PGF_<2α> and PGE_2 exert different roles on follicles : PGF_<2α> seems to induce ovulation through the mediation of progesterone , while PGE2 seems to be implied in the start and the sustaining of oocyte vitellogenic development through the mediation of estradiol.
1993-04-15