Physiological Evaluation of the Role of the Liver as a Mediator of the Growth-Promoting Action of Somatotrophin

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概要

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• The role of the liver as a mediator of the somatotrophic actions of GH was investigated in three experiments in hypophysectomized rats. The GH was infused via osmotic minipumps into the hepatic portal vein (HPV) or the external jugular vein (EJV) for 7 days at a constant rate or in 8 pulses of 1 hour each/day. Infusion of rat (r) GH at 1 μg/rat/day into the two vessels in rats hypophysectomized one day after catheterization failed to affect body growth, but it increased their tibial epiphysial plate width (TEPW), and serum IGF-I concentration to the same degree regardless of the site of delivery or the schedule of infusion. When bovine (b) GH was infused at (50 μg/rat/day) starting 12-14 days after hypophysectomy, the EJV route was more effective at stimulating growth and elevating serum IGF-I than was HPV infusion by both modes of delivery, and constant infusion was more effective than pulsed delivery. In the third experiment human (h) GH infusion was started 30 days after hypophysectomy at 50 μg/rat/day. This treatment caused much more striking growth responses than did either of the other two GH preparations, and the EJV route of delivery was again more effective than was infusion into the HPV by both schedules . In addition , the constant mode of delivery was again more effective than was pulsed infusion. These results indicate that effects of GH on peripheral tissues may be more important for growth than effects mediated by the liver. Thus, the hepatic effects of GH may involve maintaining the responsiveness of the liver to other regulators of IGF-I secretion.

• 社団法人日本動物学会の論文
• 1993-04-15

著者

• Katz S.

  Department Of Animal Sciences Cook College Rutgers University

• Russell M.

  Department Of Integrative Biology The Cancer Research Laboratory And Group In Endocrinology Universi

• Schlechter L.

  Department of Integrative Biology, The Cancer Research Laboratory and Group in Endocrinology, University of California

• Nicoll S.

  Department of Integrative Biology, The Cancer Research Laboratory and Group in Endocrinology, University of California

• Schlechter L.

  Department Of Integrative Biology The Cancer Research Laboratory And Group In Endocrinology University Of California

• Nicoll S.

  Department Of Integrative Biology The Cancer Research Laboratory And Group In Endocrinology University Of California

• Schlechter Nicole

  Department of Integrative Biology, The Cancer Research Laboratory and Group in Endocrinology, University of California

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• Physiological Evaluation of the Role of the Liver as a Mediator of the Growth-Promoting Action of Somatotrophin

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