Developmental and Pharmacological Studies of Acetylcholinesterase-defective Mutants of Caenorhabditis elegans

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Three genes (ace-1, ace-2, and ace-3), which code for acetylcholinesterase (class A, B, and C) have been identified in the nematode Caenorhabditis elegans. Here we investigate the developmental and pharmacological properties of mutants retaining only one of distinct classes of acetylcholinesterase. Both class A and B acetylcholinesterases share about one-half of the total enzyme activity throughout development and maximum specific activity at the first larval stage, and are sufficient for maintaining normal acetylcholine levels. Although class B acetylcholinesterase is distributed at the head and the body region as seen in the wild type, the class A enzyme is biased towards the head region. Class C acetylcholinesterase occupies only a few percent of the total activity, is mainly distributed in the body, shows maximum specific activity at the late larval stage and is clearly different in pharmacological response from class A and B acetylcholinesterases. We propose that class B is the major acetylcholinesterase, and that classes A and C are supplementary.
社団法人日本動物学会の論文
1993-02-15