Cellular and Molecular Aspects of Embryonic Induction

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概要

• 論文の詳細を見る

• A homogeneous protein, which induces mesodermal and endodermal tissues in amphibian gastrula ectoderm ("vegetalizing factor") has been isolated from chicken embryos. Inducing factors with similar chemical properties have been found in the Xenopus XTC-cell line and in calf kidney. The factors belong to evolutionary conserved proteins, which may also have regulatory functions in later differentiation processes or the maintenance of differentiation. They are related to the TGF-β protein superfamily. Members of this and of the FGF protein family induce mesodermal tissues. In early embryos mesoderm inducing factors show a graded distribution. Masked maternal neural inducing factors are in part activated after the cleavage stages. They have been partially purified from Xenopus embryos. We could show that phorbolester evokes neural differentiation, suggesting a signal transduction mechanism which may include phospholipases and protein kinases.

• 社団法人日本動物学会の論文
• 1990-04-15

著者

• Tiedemann H

  Freie Univ. Berlin Berlin Deu

• TIEDEMANN HEINZ

  Institut fur Molekularbiologie und Biochemie, Freie Universitat Berlin

• Tiedemann Heinz

  Institut fur Molekularbiologie und Biochemie der Freien Universitat Berlin

関連論文

• Cellular and Molecular Aspects of Embryonic Induction
• Neural induction in embryos
• Determination, induction and pattern formation in early amphibian embryos
• Neural inducing factors from Xenopus laevis eggs and embryos

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