A Human Embryo Fibroblast-Derived Peptide Suppresses the Formyl-Met-Leu-Phe (FMLP)-Induced Activation in Human Polymorphonuclear Leukocytes : COMMUNICATION : Cell Biology

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概要

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• Previously, the author and co-researchers reported a novel petide in the serum-free culture medium conditioned by a human embryo fibroblast cell strain (YH-1), which exhibited an inhibitory effect on the proliferation and some functions of B and T lymphocyies (Okai et al., Zool. Sci. 4: 99, 1987). In this paper, the effect of the fraction containing this peptide on formyl-Met-Leu-Phe (FMLP)-induced activation of human polymorphonuclear leukocytes (PMNs) is described. This fraction suppressed both the FMLP-induced chemotaxis and RNA synthesis in human PMNs, while it showed no significant cytotoxic effect on human PMNs as judged by a dye exclusion test. The inhibitory activity by this fraction was lost by a treatment with trypsin, but not heat at 60℃ for 30min. These findings indicate that the fibroblast-derived peptide has an immunosuppressive activity against the activation of human PMNs.

• 社団法人日本動物学会の論文
• 1989-06-00

著者

• Okai Yasuji

  Toxicological Research Laboratories Kyowa Hakko Kogyo Co.

関連論文

• A Human Embryo Fibroblast-Derived Peptide Suppresses the Formyl-Met-Leu-Phe (FMLP)-Induced Activation in Human Polymorphonuclear Leukocytes : COMMUNICATION : Cell Biology

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