Spontaneous Release of B Lymphocyte-Enhancing Factors for Growth and Differentiation by YH-1 Cells in Serum-Free Culture Media : Identification of Interleukin 1 Activities : Immunology

スポンサーリンク

概要

• 論文の詳細を見る

• The partially purified fraction of the serum-free culture medium conditioned by a human embryo fibroblast cell strain (YH-1) significantly enhanced proliferative responses and polyclonal antibody (immunogrobulin M and G) production by murine and human B lymphocytes. This fraction did not show significant interleukin 2 or interferon activity. The B cell-enhancing activity by the YH-1 fibroblast-derived fraction was almost completely inactivated by the treatment with the antisera against human interleukin 1 α and β. In additon, thymocyte proliferative responses by this fraction were also suppressed by the same antisera. These results indicate that the factors released from YH-1 cells are similar to interleukin 1. The biological significance of this finding is discussed from the viewpoint the immunological regulation between fibroblasts and lymphocytes.

• 社団法人日本動物学会の論文

著者

• Ishizaka Shigeaki

  3rd Department Of Internal Medicine Nara Medical College

• Okai Yasuji

  Tokyo Research Labs. Kyowa Hakko Kogyo Co.:(present)department Of Molecular Genetics Beckman Researc

関連論文

• Spontaneous Release of B Lymphocyte-Enhancing Factors for Growth and Differentiation by YH-1 Cells in Serum-Free Culture Media : Identification of Interleukin 1 Activities : Immunology

スポンサーリンク