Auditory Evoked Potentials Dynamically Related to Sleep-Waking States in Unrestrained Rats : Physiology

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Auditory evoked potentials (AEPs) to continuous click stimuli delivered at 1-s intervals were bipolarly recorded between the frontal and the fronto-parietal cortex in freely behaving rats throughout the first 3hours of the light and the dark period. Dynamic changes in the middle and late latency components of AEPs were serially analyzed during slow wave sleep (SWS), paradoxical sleep (PS) and wakefulness (W). The sleep-waking stages affected greatly the latency of the first and second negative (N_1 and N_2) and positive (P_1 and P_2) waves. Especially during SWS, N_2 and P_2 dynamically changed: the deeper SWS, as evidenced by an elevated delta activity, was accompanied by the longer latency and the higher amplitude. The peak-to-peak voltage difference was maximal when delta-sleep occurred. During PS, AEPs remained quite stable, exitibiting a steady level of N_2 and P_2 amplitudes and no fluctuation of their latencies. During W, N_2 tended to decrease in amplitude and sometimes disappeared due to habituation to the stimuli. Significant circadian variations were found in the latency and amplitude of the middle and late AEP components. Thus, the state-dependent and time-of-day-dependent characteristics of AEPs might be utilized as a good indicator for sleep-vigilance scoring.
社団法人日本動物学会の論文
1988-04-15