The Role of Endoplasmic Reticulum in Genesis of Complex Oscillations in Pancreaticβ-cells (Special Section on Nonlinear Theory and its Applications)
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概要
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In this paper, Cherry's bursting pancreatic B-cell model is updated to include a role for [Ca^<2+>]_<ER>, the luminal calcium concentration in the endoplasmic reticulum (ER). The model contains a calcium current which is activated by voltage and inactivated by [Ca^<2+>]_i. It also contains a cationic non-selective current (I_<NS>) that is activated by depletion of luminal Ca^<2+> in the ER. In this model, [Ca^<2+>]_<ER> oscillates slowly, and this slow dynamic drives electrical bursting and the [Ca^<2+>]_i oscillations. This model is capable of providing answers to some puzzling phenomena, which the previous models could not (e.g.,why do single pancreatic B-cells burst with a low frequency while the cells in an islet burst with a much higher frequency ?).Verification of the model prediction that [Ca^<2+>]_<ER> is a primary oscillator that drives electrical bursting and [Ca^<2+>]_i oscillations in pancreaticβ-cells awaits experimental testing. Experiments using fluorescent dyes such as mag-fura;2-AM could provide relevant information.
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- 1996-10-25