A Correlation-Based Motion Correction Method for Functional MRI

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One serious problem affecting the rest and active state images obtained during a functional MRI(fMRI)study is that of involuntary subject movements inside the magnet while the imaging protocol is being carried out. The small signal intensity rise and small activation areas observed in the fMRI results, such as the statistical maps indicating the significance of the observed signal intensity difference between the rest and active states for each pixel, are greatly affected even by head displacements of less than one pixel. Near perfect alignment in the subpixel level of each image with respect to a reference, then, is necessary if the results are to be considered meaningful, specially in a clinical setting. In this paper we report the brain displacements that take place during a fMRI study with an image alignment method based on a refined crosscorrelation function which obtains fast(non-iterative)and precise values for the inplane rotation and X and Y translation correction factors. The performance of the method was tested with phantom experiments and fMRI studies using normal subjects executing a finger-tapping motor task. In all cases, subpixel translations and rotations were detected. The rest and active phases of the time course plots obtained from pixels in the primary motor area were welldifferentiated after only one pass of the motion correction program, giving enhanced activation zones. Other related areas such as the supplementary motor area became visible only after correction, and the number of pixels showing false activation was reduced.
社団法人電子情報通信学会の論文
1998-06-25

A Correlation-Based Motion Correction Method for Functional MRI

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