On Creating Reference Maps for Evaluation of Ultrasound Images of Carotid Plaque

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For the purpose of developing ultrasonic tissue classification methods, this work investigates a method to create reference maps of biological tissue. Specifically, formalin fixed carotid atherosclerotic plaque was molded into an agar block containing at set of fiducial markers. The block was scanned with spatial compound ultrasound at 7.5 MHz. Both tissue and fiducial markers were imaged. The block was afterwards sliced at the location of the fiducial markers. The slices were then photographed and analyzed histologically. From this data, reference maps with the same geometry as the ultrasound images were created. For each pixel in the ultrasound image, these reference maps indicate tissue type, such as collagen poor tissue, collagen rich tissue, etc. Because the histological method could not identify calcification with certainty, alternative methods (e.g. X-ray) had to be included to ensure proper identification of calcification.
社団法人電子情報通信学会の論文
2002-10-18

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