原発性マクログロブリン血症,多発性骨髄腫をはじめとするparaprotein血症に対する治療的ヘムアフェレシス

概要

論文の詳細を見る
Therapeutic haemapheresis, especially therapeutic plasmapheresis has been widely applied for the treatment of primary macroglobulinemia, multiple myeloma and other paraproteinemias because pathogenesis and pathogenic substances are well understood, and these substances are removable by haemapheresis. In the case of treatment for abnormalities associated with primary macroglobulinemia, multiple myeloma and light chain disease, simple plasma exchange is recommended because the quantity of paraproteins is too large to perform effective plasmapheresis by selective removal. As far as hepatic function is not severely impaired, it is not necessary to use fresh frozen plasma as a replacement fluid. If the concentration of the pathogenic paraprotein is low, selective plasmapheresis is recommended. Some plasma cell dyscrasias, for example Crow-Fukase syndrome, show characteristic symptoms and a high plasma concentration of cytokines in these diseases is candidate for causative agents of clinical manifestations. Some authors reported effective haemapheresis against these diseases. It is important to investigate the efficacy of therapeutic haemapheresis for the treatment of plasma cell dyscrasias with accerelated cytokine concentration.
日本アフェレシス学会の論文
1999-11-30