潰瘍性大腸炎(UC)に対する白血球系細胞除去療法の試み : 遠心分離法を用いた白血球系細胞除去療法

概要

論文の詳細を見る
A centrifugal leukocytapheresis therapy was applied in the treatment of patients with intractable inflammatory bowel diseases : two patients with ulcerative colitis and one with Crohn's disease. The treatment was performed once a week, 4 times. A total of 300 ml of white blood cell compartments were sequestrated from 3,500-4,000 ml of extracorporeally circulated blood with a computer-controlled system for 60-70 minutes per procedure. As a result, the removed blood cell number was 3.5±1.1×10^9 of WBC, 0.5±0.4×10^9 granulocytes, and 2.6±0.6 × 10^9 lymphocytes. Lymphocytes in the removed blood compartments were statistically proportional to those in peripheral blood (γ=0.863). Clinically, this therapy ameliorated the patient's genera condition, with normalized CRP levels and increased serum albumin and hematocrit levels. There were no adverse effects during the course of this therapy. These results suggest that the present centrifugal leukocytapheresis method is effective and safe in the treatment of patients with ulcerative colitis and Crohn's disease.
日本アフェレシス学会の論文
2000-02-29