自家骨髄細胞移植による血管新生療法

概要

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Therapeutic angiogenesis is an effective means for tissue salvage in patients with critical limb ischemia. Angiogenesis is defined as a formation of new blood vessels by the sprouting of preexisting mature endothelial cells (ECs). In contrast, vasculogenesis is referred to as the creation of primordial blood vessels from endothelial progenitor cells (EPCs) or angioblasts. Neovascular formation in adults has been considered to result exclusively from the former process (i.e., angiogenesis). However, we and other researchers recently identified EPCs in human peripheral blood (PB), and circulating EPCs have been shown to accumulate at active angiogenic sites and to participate in neovascularization, a notion consistent with "postnatal vasculogenesis." EPCs in adults are believed to originate from bone marrow (BM), and we recently demonstrated that an in vivo implantation of autologous BM-MNCs effectively augmented ischemia-induced neovascularization in experimental animals and humans. Here, we summarize recent advances in cell transplantation-mediated therapeutic angiogenesis.
日本アフェレシス学会の論文
2002-05-31