Different regulation of intercellular junctional proteins; Connexin 43, occludin, claudin-1 , and VE-cadhein in the perineurium during nerve regeneration after crush-injured rat sciatic nerve
スポンサーリンク
概要
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To characterize changes in the localizations of the intercellular junctional proteins during nerve regeneration after crush injury, we performed analysis of the expression of four intercellular junctional proteins: connexin (Cx) 43 for gapjunctions, VE-cadherin for adherens junctions, and occludin and claudin-1 for tight junctions in the perineurium of crush-injured rat sciatic nerves using immunofluorescence and confocal laser scanning microscopy. After crush injury, migrating perineurial cells did not express intercellular junctional proteins in the crush site on 1 day after release from thread. Expressions of occludin, claudin-1 and VE-cadherin were recovered on 2 days after the release, whereas Cx 43 was detected on 5 days after the release. These results indicate that the normal expression of these intercellular junctional proteins in the perineurium is initially lost but recover in a different spatiotemporal manner. Re-establishment of intercellular junctions in the perineurium may be important in the maintenance of the axonal microenvironment.
- 日本組織細胞化学会の論文
著者
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Oyamada Masahito
Dept. Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine
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Hirakawa Hisanori
Dept. of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Nagaoka Takanori
Dept. of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Takamatu Tetsuro
Dept. of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Nagaoka Takanori
Dept. Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine
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Hirakawa Hisanori
Dept. Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine
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Takamatu Tetsuro
Dept. Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine