Nerve growth factor applied onto the olfactory epithelium alleviates the degenerative changes of the olfactory receptor neurons following axotomy

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The olfactory neuroepithelium has an unique capability in the mammalian nervous system because continuous neurogenesis occurs throughout lifetime. Recent studies suggested that neurotrophic factors and their receptors may play a role in the regulation of development and regeneration in the olfactory system. However, there has been very few studies investigating the effect of exogenous neurotrophic factors in the olfactory system in vivo. In the present study, we have administered nerve growth factor and brain-derived neurotrophic factor into the rat olfactory mucosa for 5 days just after the transection of the olfactory nerve, and have examined the effect of exogenous neurotrophic factors on the degenerative changes in axotomized olfactory receptor neurons (ORNs). And we also examined the localization of their receptors, Trk A and Trk B. We found that both mature and immature ORNs expressed more signals for olfactory marker protein and beta-tubulin mRNAs, respectively, when NGF was given on the axotomized olfactory neuroepithelium for five days, compared to the salinetreated control ORNs. BDNF at 10 ug of total dose did not show the effect. The effect of NGF applied onto the oflactory epithelium in consistent with the immunohistochemical data that Trk A was present in the dendrite and axonbundle in normal and axotomized ORNs. These results suggest that NGF may alleviate the degenerative changes in mature and immature ORNs following the axotomy through the binding to trk A receptor located in the surface of the olfactory epithelium.
日本組織細胞化学会の論文

Nerve growth factor applied onto the olfactory epithelium alleviates the degenerative changes of the olfactory receptor neurons following axotomy

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