Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO)in Rat Gastric Parietal Cells

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概要

• 論文の詳細を見る

• Histamine as an acid secretagogue and H_2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included immunohistocytochemical localization and biochemical enzyme activity of glutathione-peroxidase, an enzyme that effectively reduces lipid peroxides. No changes in lipid peroxidation, in response to the H_2-blocker, were observed, however its accumulation in the vicinity of vacuole-like structures was specific to proton pump inhibition. This finding suggests that lipid peroxidation occurs in local parietal cells.

• 日本組織細胞化学会の論文

著者

• Kimura Norio

  Division Of Gasfroenterology Ii Tokai University School Of Medicine

• Miwa T

  Univ. Electro-communications Chofu‐shi Jpn

• Miwa Takashi

  Division of Gastroenterology II, Tokai University School of Medicine

• Miwa Takashi

  Division Of Diabetes Metabolism And Endocrinology Third Department Of Internal Medicine Tokyo Medica

関連論文

• Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO)in Rat Gastric Parietal Cells
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