IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON BETA CELL DESTRUCTION IN NOD MOUSE, AN ANIMAL MODEL FOR TYPE I DIABETES MELLITUS

概要

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Non-obese diabetic (NOD) mice were recently established as a model for type I diabetes mellitus. Immunohistochemical study revealed that Thy-1^+ cells (most of the cells are Lyt 1^+ but some are Lyt 2^+) infiltrate pancreatic islets and selectively destroy beta cells, resulting in overt diabetes. Immunoelectron microscopical study demonstrated the contact of both Lyt 1^+ and Lyt 2^+ cells with beta cells. A close adhesion of Lvt 2^+ cells to beta cells was regularly observed, and pseudopodia-like protrusions of the organella-rich Lyt 2^+ cells into the beta cells, resulthg in the degeneration of those cells, were frequently seen. By contrast, Lyt 1^+ cells were merely in loose contact with beta cells. These results suggest that Lyt 2^+ cells are involved in the direct destruction of beta cells in NOD mice.
日本組織細胞化学会の論文