FINE STRUCTURAL LOCALIZATION OF ACID PHOSPHATASE IN GIANT CELL TUMORS OF BONE

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概要

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• The fine structural localization of acid phosphatase activity was studied by Gomori's method in the four cases of giant cell tumors of bone. In the stromal cells, the final reaction product was deposited over lysosomes. And in the multinucleated giant cells, the final product was deposited over lyso-some-like organelles and also over the digestive vacuoles of autophagic or of a little heterophagic origin. These vacuoles were suspected to be secondary lysosome-like organelles in various stages. No deposits of reaction product were observed in giant cells in media containing sodium fluoride, L-(+)-tartrate, or those lacking the substrate. Degenerating giant cells containing autophagic secondary lysosome-like organelles were sometimes observed. It is suspected that their ultimate fates are cell death or autolysis and that acid phosphatase is excreted in these occa-sions from the cytoplasm to the extracellular medium.

• 日本組織細胞化学会の論文

著者

• Morisawa Keizo

  Department Of Orthopaedic Surgery Kumamoto University Medical School

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