FINE STRUCTURE OF HALOPERIDOL BINDING SITES IN THE NEOSTRIATUM : AN ULTRAIMMUNOHISTOCHEMICAL ATTEMPT TO VISUALIZE HALOPERIDOL/DOPAMINE RECEPTORS

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概要

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• Following intrastriatal microinjection of haloperidol, the binding sites were demonstrated using ultraimmunohistochemistry. Haloperidol immunoreactive neurons began to appear 1 hr after the injection and dispersed far from the injection site as time passed. Electron microscopically, haloperidol binding sites were visualized as a soluble form. The immunoreaction products were seen throughout the cytoplasm but avoided the nuclear membrane, cisternal structures and most of the mitochondria. The haloperidol immuno-reaction products showed shading differences in each cytoplasm, which was understood to be due to various states of affinity to the ligand. Based on these findings, a new concept of receptors is proposed: There are spare receptors before functioning and active receptors having a higher affinity for the ligand. Four out of six neuronal types in the rat neostriatum, according to the classification by Kaiya et al. (13, 15), showed haloperidol immunoreaction products.

• 日本組織細胞化学会の論文

著者

• Kaiya Hisanobu

  Department Of Neuropsychiatry Gifu University School Of Medicine

関連論文

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• FINE STRUCTURE OF HALOPERIDOL BINDING SITES IN THE NEOSTRIATUM : AN ULTRAIMMUNOHISTOCHEMICAL ATTEMPT TO VISUALIZE HALOPERIDOL/DOPAMINE RECEPTORS
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