ALTERATIONS IN THE NORADRENALINE-CONTAINING NERVE TERMINALS IN THE PERIVENTRICULAR PORTION OF THE RAT HYPOTHALAMUS FOLLOWING ADMINISTRATION OF CHLORPROMAZINE

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概要

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• Noradrenaline terminals in the periventricular hypothalamic region of the rat were visualized electron microscopically using a KMnO_4 fixation technique. Alterations of these terminals were examined following chronic treatment of chlorpromazine (CPZ; 20 mg/kg) for one month. In the control rats, noradrenaline terminals with a typical synaptic contact accounted for only 7% of the total number of noradrenaline terminals. After 12 days of daily administration of CPZ, noradrenaline terminals with typical synapses increased markedly to approximately 3.5 times over those seen in the controls. In addition, these terminals with a synapse-like formation also increased up to 2.5 times the number in the controls 30 days after chronic injections of CPZ. On some occasions, daily administration of CPZ for over 20 days resulted in degenerative changes of the noradrenaline terminals which contained membranous structures.

• 日本組織細胞化学会の論文

著者

• Kashiba Akira

  Research And Laboratory Division Nakamiya Mental Hospital

関連論文

• ALTERATIONS IN THE NORADRENALINE-CONTAINING NERVE TERMINALS IN THE PERIVENTRICULAR PORTION OF THE RAT HYPOTHALAMUS FOLLOWING ADMINISTRATION OF CHLORPROMAZINE
• ALTERATIONS IN NORADRENALINE NERVE TERMINALS IN THE PERIVENTRICULAR HYPOTHALAMUS OF THE RAT DURING REGENERATION AFTER ADMINISTRATION OF 6-OH DOPAMINE

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