RENAL CRYSTALLINE DEPOSITION AND ITS PATHOGENESIS
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One thousand autopsy cases were studied in regard to the pathological factors of renal crystalline deposition, using the histochemical method for calcium salts by the present author, and the grade of its deposition was quantitatively determined (-∼〓). 1) Calcium oxalate crystals (CaOX) and leucine like crystals (LLC), which have both birefringency and have been often confused, were confirmed to be distinguished. This study clarifyed that the LLC presented an isogyre by a polarizing microscope and was dissolved in 5% potassium hydroxide being different from the CaOX. 2) Two hundreds cases with birefringent crystals among 1000 were divided into three groups: CaOX group 67 cases (6.7%), CaOX+LLC group 28 cases (2.8%), LLC group 105 cases (10.5%). 3) The incidence of the crystalline deposition was lower under 16 years of age and no sex difference was observed. 4) Lesions with a high incidence among 200 cases were renal and hepatic, regressive changes (metabolic disorders), hydrops of cavities and malignant neoplasms. Renal tubular degeneration was found particulary to have a high incidence and was regarded as an important factor for crystalline deposition. 5) Grade (〓) was found in the highest incidence in the CaOX group, in which the renal diseases were dominant, and grade (+) was the highest in the LLC group, which seemed to have a close relation to hepatic lesions with jaundice. The CaOX+LLC group was intermediate between both groups. 6) Cases with malignant neoplasms were found in about one half of the 200 cases, however, no difference in the incidence of crystalline deposition between cases with and without malignant neoplasms was detected.
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関連論文
- RENAL CRYSTALLINE DEPOSITION AND ITS PATHOGENESIS
- HISTOCHEMICAL IDENTIFICATION OF CALCIUM OXALATE
- A New Histochemical Method for Calcium Oxalate