POSSIBLE ROLE OF LYSOSOMES IN CELLS OF "THE EPITHELIOID CELL SYSTEM" (PHYSIOLOGY AND PATHOLOGY OF LYSOSOMES)

スポンサーリンク

概要

• 論文の詳細を見る

• Granulomatous lesions which were induced with living BCG, heat-killed BCG and mycobacterial fraction (glycolipid) in rabbit lungs were studied by electron microscopy. The transformation of macrophages into epithelioid cells and giant cells observed in granulomatous lesion was named "the epithelioid cell system". According to lysosomal function, this system can be divided into three stages: (1) heterophagic stage, (2) intermediate stage and (3) autophagic stage. At every stage dense cuplike structures in the plasma membrane and the Golgi-associated tubular system in cytoplasm were observed. By biochemical assay of granulomatous lesion lysosomal cathepsin B revealed a correlative increment of specific activity on time course after pulmonary inoculation. Cathepsin B and lysozyme showed a high level of specific activity. However, specific activity of lysozyme in granulomatous lesion induced with living BCG was higher than that in granulomatous lesion induced with mycobacterial glycolipid.

• 日本組織細胞化学会の論文

著者

• Nishi Kenichi

  Laboratory Of Cellular Pathology Toneyama National Hospital

関連論文

• POSSIBLE ROLE OF LYSOSOMES IN CELLS OF "THE EPITHELIOID CELL SYSTEM" (PHYSIOLOGY AND PATHOLOGY OF LYSOSOMES)

スポンサーリンク