FUNCTIONAL ASPECTS OF THE PANCREATIC LANGERHANS ISLETS IN STARVED ANIMALS BASED ON THE HISTOCHEMICAL AND ELECTRON MICROSCOPICAL OBSERVATION

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概要

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• The histochemical and electron-microscopic investigations were performed on the functional aspects in the islet cells in starved rats, rabbits and guinea pigs. Histologically, in starved animals, an atrophy of the B-cells was observed while the A-cells rather showed an increase in number. Ultramicroscopically, the alterations in the exhausted condition induced by starvation, as indicated by the appearance of lipid droplets or ceroid substance, were observed not only in the B-cells but also in the A-cells. On the contrary, in all starved animals, the tendency was demonstrated, electron-microscopically, that the B-cells appeared to be suppressed in their secretory function, whereas the A-cells appeared to be stimulated. Enzyme-histochemical observations on the islets after fasting showed a decrease in the activity of Ac-Pase (rat and rabbit), G6Pase (rabbit and guinea pig), 5'Nase (rat) and IDPase, while an increase in the activity was demonstraied on ATPase, nonsp.Est., Al-Pase (rat) and many of the enzymes concerning glucose oxidation. Enzyme activities in both the A-cells and the B-cells, determined histochemically, showed a synergistic alteration, and no antagonistic relationship was detected, although it was suggested under an electron microscope that, from the point of secretory function, the A-cells showed an antagonistic functional state to the B-cells.

• 日本組織細胞化学会の論文

著者

• Kaito Hiroshi

  Department Of Pathology Faculty Of Medicine Kyoto University

• Kaito Hiroshi

  Department Of Nephrology National Defense Medical College

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