β-ADRENERGIC EFFECTS ON SALIVARY GLANDS: GROWTH AND GENE REGULATION

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概要

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• In the parotid and submandibular glands β-adrenergic receptors play a pivotal role in regulating differentiation, cell replication and cellular and organ growth. Administration of the β-adrenergic agonist, isoproternol, to rats or mice stimulates DNA synthesis and cell division of acinar cells, and given chronically, it produces marked hyperplastic/hypertrophic enlargements of these organs. The mechanisms by which IPR induces DNA synthesis and cellular hypertrophy are not known. A useful approach of analyzing these processes involves the identification of genes whose expression is regulated by β-adrenergic receptors. Several groups of genes regulated by adrenoreceptors in the salivary glands have now been identified. These include the proto-oncogenes c-fos, c-myc, c-abl, the family of proline-rich proteins, a cysteine proteinase inhibitor cystatin S, and 4β-galactosyltransfeiase. Further studies are required to characterize genes which are positively or negatively regulated byβ-adrenergic receptors in salivary glands, and to establish the relevance of the expression of these genes to control mechanisms of cell replication and growth.

• 日本組織細胞化学会の論文

著者

• Barka T

  City Univ. New York N.y. Usa

• Barka Tibor

  Department Of Anatomy Mount Sinai Schooll Of Medicine Of The City University Of New York New York U.

• Ashihara Tsukasa

  Anatomy and Pathology, Mount Sinai School of Medicine

関連論文

• EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDES IN MOUSE SUBMANDIBULAR GLAND.
• Expression of Cystatin C in Human Histiocytic Lymphoma, U-937, Cells
• β-ADRENERGIC EFFECTS ON SALIVARY GLANDS: GROWTH AND GENE EXPRESSION.
• β-ADRENERGIC EFFECTS ON SALIVARY GLANDS: GROWTH AND GENE REGULATION

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