HISTOCHEMICAL STUDIES ON MUCOSUBSTANCE IN HUMAN GASTRIC CARCINOMA

概要

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Histochemical observations on mucosubstance are studied in total 270 specimens which are composed of 200 specimens (or 265 tissue blocks) of gastric carcinomas, 50 specimens of non-cancerous gastric tissues, and 20 specimens of duodenal and rectal tissues. The results are summariezd as follows: 1. In the normal and non-cancerous gastric mucoas, two types of mucosubstance are distinguished histochemically: Mucosubstance proper to gastric mucosa (stomach type or S-type) being stained various tints of red in colour by AB-PAS method (PAS-positive and AB-negative), and mucosubstance specific for goblet cells in the area of intestinal metaplasia (goblet type or G-type), being stained blue to purple by AB-PAS method (positive for both AB and PAS). 2. The incidence of G-type mucosubstance in gastric carcinoma tissues is unexpectedly high, amounting to 157 out of 200 specimens or 78.5 per cent; or 212 out of 265 blocks or 80.0 per cent. 3. The incidence of G-type mucosubstance in the early (intramucosal) carcinoma of the stomach is 51/65 (78.5%), and this is quite similar to that in the advanced carcinoma, 106/135 (78.5%). 4. According to these findings, a close relationship of G-type mucosubstance in the gastric carcinomas to the goblet cells of intestinal metaplasia is assumed, and a possible roll of the intestinal metaplasia in a histogenesis of the gastric carcinoma is considered.