APC Is Colocalized with β-Catenin and hDLG in Henle's Loop of the Mouse Kidney

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概要

• 論文の詳細を見る

• The tumor suppressor gene adenomatous polyposis coli (Apc) is mutated in familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the Apc gene (APC) has been found to bind to β-catenin and human homolog of discs large (hDLG), and to be involved in the Wnt/Wingless signaling pathway. In this study, we examined distribution and subcellular localization of APC and its colocalization with β-catenin and hDLG in the mouse kidney by immunohistochemistry and immunoelectron microscopy. APC was highly expressed throughout the medullary region of the kidney, and localized mainly in the basal cytoplasm of epithelial cells of the thin portion of Henle's loop. It was found that APC was colocalized with β-catenin and hDLG by double-immunolabelling at both light- and electron-microscopic levels. these results suggest that APC complexed with β-catenin and hDLG may be involved in some signaling pathways regulating cellular functions of Henle's loop epithelial cells.

• 日本組織細胞化学会の論文

著者

• Nishimura Yusuke

  Department of Regulation Biology, Faculty of Science, Saitama University

• SENDA Takao

  Department of First Department of Anatomy, Nagoya University School of Medicine

• AKIYAMA Tetsu

  Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, T

• Nishimura Yusuke

  Department Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine Labor

• Senda Takao

  Department Of Anatomy And Cell Biology Nagoya University School Of Medicine

• Senda Takao

  Department Of Anatomy Osaka University Medical School

• Akiyama Tetsu

  Department Of Molecular And Genetic Information Institute Of Molecular And Cellular Biosciences Univ

• Akiyama Tetsu

  Laboratory Of Molecular And Genetic Information Institute For Molecular And Cellular Biosciences The

• Kakinuma Naoto

  Department Of Molecular And Genetic Information Institute Of Molecular And Cellular Biosciences Univ

• Kakinuma Naoto

  Laboratory of Molecular and Genetic Information, Institute of Molecular and Biological Sciences, The

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