Morphological and Immunohistochemical Studies of Angiogenesis in Endometrial Cytological Preparations

概要

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Because angiogenesis is indispensable to the growth, invasion and metastasis of tumors, we conducted this study to elucidate the process of angiogenesis and the morphology of the new vessels in endometrial aspirated specimens. Cellular specimens from 21 cases of well differentiated endometrioid adenocarcinoma were employed in the investigation. Immunohistochemical staining was performed according to cell type using a CD34 monoclonal antibody as a vascular endothelial cell marker and α-smooth muscle actin as a pericyte marker. Microprojections that appeared to be sprouts of endothelial cells and finger-like processes that resembled endothelial cell extensions from the initial stage of angiogenesis were seen in a portion of the vascular network. Scattered cul-de-sacs that were in the process of extending into avascular fields were also observed. In some cases where several cul-de-sacs were observed, fork-like vessels were also seen, indicating that vigorous angiogenesis was occurring. This study elucidated the process of angiogenesis and the morphology of the new vessels in endometrial aspirated specimens.
日本組織細胞化学会の論文
2000-00-00