Expression of p27^<Kip1> in Normal, Hyperplastic and Neoplastic Endocrine Tissues (Symposium IRegulation of Endocrine Function)

スポンサーリンク

概要

• 論文の詳細を見る

• p27^<Kip1> (p27) is a member of the cyclin dependent kinase inhibitor (CDKI) family of cell cycle proteins. We analyzed p27 expression in normal endocrine cells, endocrine cell hyperplasia, adenomas and carcinomas. The levels of p27 protein expression decreased during tumor development and progression. This decrease occurs mainly at the post-translational level with protein degradation by the ubiquitin-proteasome pathway. These results indicate that p27 may be a useful immunohistochemical marker to help separate normal from hyperplastic endocrine cells and adenomas from carcinomas.

• 日本組織細胞化学会の論文

著者

• Lloyd Ricardo

  米国

• Lloyd R

  Mayo Clinic And Mayo Foundation Minnesota Usa

• Lioyd Ricardo

  Department Of Laboratory Medicine And Pathology Mayo Clinic And Mayo Foundation

関連論文

• ヒト下垂体腺腫より樹立された細胞株 HP 75の性状解析
• P-28-B 多ホルモン産生下垂体腺腫の分子機構の解析(生殖器・内分泌,ポスター発表,第44回日本組織細胞化学会 第35回日本臨床電子顕微鏡学会 合同学術集会)
• Immunophenotyping Combined with Laser Capture Microdissection (Immuno-LCM)
• Expression of p27^ in Normal, Hyperplastic and Neoplastic Endocrine Tissues (Symposium IRegulation of Endocrine Function)

スポンサーリンク