アダカラムを用いた顆粒球・単球除去療法

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概要

• 論文の詳細を見る

• The Adacolumn is an extracorporeal granulocytes and monocytes adsorption column. The Adacolumn contains bead-type adsorbent made from cellulose diacetate. The beads are 2 mm in diameter and 60 degrees in contact angle with water. This column removes 20-40% of granulocytes and monocytes from introduced peripheral blood. The removal rate for lymphocytes and platelets is about 5%. Usually blood is drawn from a vein and is returned via another vein. Blood flow rate is 30 mL/min and the extracorporeal method consists in direct hemoperfusion. The Adacolumn has been applied to various kinds of autoimmune diseases and inflammatory diseases, and is now confirmed effective for rheumatoid arthritis and ulcerative colitis. In Japan, the population of patients with ulcerative colitis has been increasing and is mainly treated with steroid. However, there are many steroid-resistant patients and the side-effects of steroid cause serious problems. Therfore, the Adacolumn will be the next standard treatment for ulcerative colitis.

• 日本アフェレシス学会の論文
• 2003-02-28

著者

• 竹中 良則

  日本抗体研究所学術部

• 竹中 良則

  (株)日本抗体研究所学術部

関連論文

• W-2-1 顆粒球吸着器の開発
• 白血球系細胞除去療法とバイオマテリアル
• 2) 顆粒球除去療法の現況と今後の展開(2. 白血球系細胞除去療法)(日本アフェレシス学会第13回関東甲信越地方会抄録)
• Venture 顆粒球吸着療法の免疫系への影響
• アダカラムを用いた顆粒球・単球除去療法
• 顆粒球吸着カラムを用いた白血球除去(技術講習会,日本アフェレシス学会第19回関西地方会抄録)

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