Nuclear Envelope Breakdown Is a Prominent Feature in Spinal Motor Neurons of Wasted Mice
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概要
- 論文の詳細を見る
It has been thought that the wasted mouse is a good model for motor neuron disease. Recently, it was found that the wasted mouse is caused by a gene defect of elongation factor 1α2, but the mechanism of the abnormal phenotype remains poorly understood. In the present study, we examined spinal motor neurons of wasted mice with light and electron microscopy. Confocal images with lamin B immunolabeling and conventional electron micrographs demonstrate that nuclear envelope breakdown (NEB) is a prominent feature of large motor neurons in wasted mice, although probable intercalated neurons or glial cells show no abnormalities. Furthermore, motor neuron death in wasted mice seems to be neither apoptosis nor necrosis. These data suggest that to understand the mechanism about NEB of the spinal motor neuron in wasted mice could shed light on certain motor neuron diseases.
- 日本組織細胞化学会の論文
著者
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Nakamura Akinori
信州大学 医学部保健学科
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Nakamura Akinori
3rd Department Of Internal Medicine School Of Medicine
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Nakamura Akinori
3rd Department Of Internal Medicine Shinshu University School Of Medicine
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Ueda Hideho
Department Of Anatomy And Cell Biology School Of Health Sciences Shinshu University
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Tezuka Hideo
Center For Life Science Research Yamanashi Medical University
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- Nuclear Envelope Breakdown Is a Prominent Feature in Spinal Motor Neurons of Wasted Mice