薬剤の腎に与える影響について : 血漿増量剤と抗生物質製剤による腎障害

概要

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Blood transfusion is often needed in surgical operation. However, blood for transfusion is insufficient recently and furthermore blood transfusion accompanies a risk of serum hepatitis. Accordingly, various blood substitutes are devised. Plasma volume increasing agent is one of them. I had used sodium arginate preparation, a plasma volume increasing agent, from 1964 to 1966. In 31 or 65.9 per cent of the 47 cases receiving this preparation an increase of serum nitrogen level probably due to it was observed. It was remarkable that a variation of serum nitrogen level was relatively small in the patients with normal renal function but radical those with lowered renal function. In addition, 14 of the 47 cases given this preparation died. Four of them autopsied. In all of them basophilic substance was found in tubular spaces of glomeruli and uriniferous tubles in the kidney without combined use of KM.
社団法人日本泌尿器科学会の論文