末期腎不全患者の免疫機能に関する研究

概要

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There are some reports indicating that the patients with chronic uremia reveal a rather suppressive immune response. The author attempted to clarify the immunological reactivity of terminal renal failure by observing the PHA induced blastoid transformation of lymphocytes in vitro system. In many cases peripheral lymphocytes from patients with terminal renal failure gave a decreased reaction to PHA, especially when they were incubated in the presence of their own serum. The recombination experiments, in which lymphocytes from patients were incubated in the presence of normal serum, or lymphocytes from normal individuals in the presence of patient's serum, suggested that there might be at least two factors to cause a decreased reaction to PHA.
社団法人日本泌尿器科学会の論文