膀胱癌に対する抗腫瘍剤膀胱内注入療法の臨床的研究

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Intravesical instillation of thio-TEPA, Mitomycin C (MMC) and 5-Fluorouracil (5-Fu) with a single or triple drug regimens has been attempted on cases of urinary bladder tumors admitted in our hospital for four years from 1966 to 1969. The instillation was usually carreied out twice a week to reach total doses of thio-TEPA 300 mg and MMC 100mg. Triple drug regimen instillation was tried with thio-TERA 20 mg, MMC 10 mg and 5-Fu 500 mg. 1) Antitumor effect of intravesical instillation 1. Thio-TEPA was applied to 29 cases of non-infiltrative bladder tumor, resulting in complete destruction in 6 cases (20.7%), Partial destructon in 14 cases (48.3%) and ineffectivenessin 9 cases On the other hand, Partial destruction was observed in 14 cases (51.9%) and without effect in 13 cases (48.1%) of 28 cases of infiltrative tumor. Complete destruction was found in no case. 2. Based on the evaluation of partial destruction, prominent or moderate destructive findings of the tumors were examined cystoscopically in the non-infiltrative cases, whereas only superficial destruction was observed in the infiltrative cases. 3. The mean dose of thio-TEPA 367 mg has been thought necessary to obtain complete destructive effect in non-infiltrative cases. However, even the mean dose of 234 mg or 204 mg seemed to show only partial destruction or no effect.
社団法人日本泌尿器科学会の論文
1972-07-20