前立腺癌に対する下垂体組織内照射法の研究 : 第2篇下垂体照射後の内分泌機能の変動と臨床効果との関係について

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Observations were made on 20 patients with prostatic cancer before and after the radiation. to pituifarg Urine gonadotropin, urine 17 ketosteroid, urine 17 hydroxycorticosteroid and urine 17 ketogenic steroid were measured. ACTH test and Metopirone test were also performed. The results were as follows : 1) Urine gonadotropin became very low within a week after a sufficient pituitary ablation. However , this low urine gonadotropin had no direct relationship with complete anatomical ablation of the pituitary gland. 2). Urine steroids continued to fall for 3 weeks after the radiation, but some patients showed temporary high levels of urine 17 OHCS and 17 KGS. 3). Metopirone test is useful to evaluate the degree of hypophysealablation, but there were some cases which had needed a long period until the slow reaction appeared. 4) Our present procedure had no influences on the adrenocortical reserve function. 5) It was Metopirone test that was most useful to determine the clinical effect of this procedures.
社団法人日本泌尿器科学会の論文