人前立腺癌の電顕的研究 : 特に前立腺癌に於けるlysosome系及び女性ホルモン大量療法の及ぼす影響について

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The fine structure of normal and neoplastic prostate before and after the administration of high dose estrogen, has been investigated by the electron histochemistry and the following results were obtained. 1)Acid phosphatase activity can be seen in the lysosomes, as well as in the granules, vesicles and vacuoles within the secretory vacuole, while no activity can be detected within the cisternae of the rough endoplasmic reticulum and Golgi apparatus. 2)Many lysosomes and large secondary lysosomes surrounded by the access of many lysosomcs are seen in the normal prostatic and the well differentiated prostatic cancer cells. 3)The large lysosomes having the internal structure are observed in the prostatic cancer cells. 4)The number of usual lysosomes are decreased and the autophagic vacuoles and the residual bodies with the distinct internal structure of myelin are increased in number at the undifferentiated prostatic cancer cells. 5)The lysosomes and large secondary lysosomes surrounded by the access of many lysosomes are also found in the basal cells of the normal prostate.
社団法人日本泌尿器科学会の論文