泌尿器科領域における腎Glutaminaseの研究

概要

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Glutaminase posseses two isozymes. One is phosphate dependent glutaminase which is activated with phosphate. Another is phsophate independent glutaminase which has an action on glutamine without phosphate. Glutaminase activities were decreased in chronic pyelonephritis, nephrophthisis, hydronephrosis and renal tumors. Phosphate dependent glutaminase activities decreased remarkably, whereas phosphate independent glutaminase activities were remained almost unchanged in the kidney with above disorders. The ureter was incompletely and unilateraly ligated in rats and rabbits to produce hydronephrosis experimentally. Observations were made for 6 weeks and for 6 months for rats and rabbits respectively. The same is also true for clinical determinations. The solution of NH_4Cl, HCI or sodium bicarbonate was given to rats. Phosphate dependent glutaminase activities in the kidney were increased remarkably by NH_4Cl, but not by other agents. The decrease of phosphate dependent glutaminase activities might be a causative factor of acidosis in urological patients with renal disorders, judging from above clinical and experimental results.
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