膀胱内注入坑菌性物質の膀胱壁内移行 : 尿路感染症に対する尿中抗菌性物質の意義について

概要

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Many works have been published on the absorption of various drugs by the bladder wall. Nevertheless, there were very few literatures regarding the transport of antibacterial drugs in the bladder wall, especially antibiotics. In regards to the transmission of antibacterial drugs to the bladder wall, two routes are theoretically inferred, namely through the blood supply to the bladder wall and through the reabsorption of the drugs by the bladder wall. The present study was designed to delineate the quantitative transport of antibacterial drugs with the emphasis on the reabsorption of antibacterial drugs into the bladder wall of the dog. 1.It was observed that Tetracycline, Colimycin and Streptomycin instilled in the bladder cavity, were transported into the bladder tissue, and were recovered in the urine through the blood stream. 2.These transports were not obviously influenced by PH or the osmolality of the solution for instillation of these drugs.
社団法人日本泌尿器科学会の論文