前立腺癌の内分泌学的研究 : 抗男性ホルモン療法のさいの性腺外Androgenの変動について(Gas Liquid Chromatographyによる尿中17-KSの分析)

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Urinary 17-ketosteroids were fractionated into androsterone, etiocholanolone and dyhydroepiandrosterone by the use of gas-liquid chromatography. Changes of urinary 17-ketosteroids, their fractions and 17-hydroxycorticosteroids following anti-androgenic treatments were investigated with special reference to extragonadal androgens. Effects of ACTH and gonadotropin (HCG and PMS) administrations on these steroid metabolites were analysed. The results were as follow : (1) Pre-treatment levels of urinary total 17KS, their fractions and 17OHCS did not differ significantly from those of the healthy controls and patients with prostatic hyperplasia. (2) Levels of urinary total 17KS, androsterone and etiocholanolone were markedly reduced following castration. The reduced levels were maintained with administration of estrogens. (3) Neither castration nor estrogen administration resulted in any alteration of ACTH response. Analysis of urinary 17KS fractionation suggested rather an elevated responsiveness. (4) Administration of HCG on castrated patients resulted in an increase of urinary androgen metabolites, suggesting an androgen-stimulating effect of HCG on the adrenal cortex. The effect was not reduced by administration of estrogens. (5) Administration of estrogens decreased both ACTH and HCG responses, probably by the route of the pituitary-adrenal axis. (6) Administration of PMS did not show any remarkable effect on excretion rates of urinary androgen metabolites both of gonadal and adrenal origins. The results suggested that the elevated responsiveness of extragonadal androgen secretion should be suppressed by continuous administration of estrogens.
社団法人日本泌尿器科学会の論文

前立腺癌の内分泌学的研究 : 抗男性ホルモン療法のさいの性腺外Androgenの変動について(Gas Liquid Chromatographyによる尿中17-KSの分析)

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