女子内分泌性膀胱症に関する研究 : 特に自律神経機能異常について

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Bladder disturbance in female which is considered to have developed under influence of imbalance of sex hormone is not infrequently encountered in daily practice. It may be adequately called "endocrine cystopathy in female". However, little is known about this trouble. To reveal how the symptoms of this disease develop, function test of the autonomic nervous system and cystometric examination were carried out in patients with this disease, and experimental study was also made on the cholinesterase (ChE) and monoamineoxidase (MAO) activities in the urinary bladder of the female mature albino rats treated with various kinds of sex hormone. 1) The function of the autonomic nervous system in patients with female endocrine cystopathy was abnormal in majority of the cases. 2) Of this dysfunction of the autonomic nervous system in this disease, it was characteristic that hypertonicity of parasympathetic nerve was mostly observed in the younger group of patients, and hypertonicity of the sympathetic nerve in the older one. 3) The function of the autonomic nervous system which had been abnormal before treatment of this disease was completely normalized in a large number of cases when the symptoms were dramatically improved by the sex hormone therapy. From this fact, it is presumed that dysfunction of the autonomic nervous system in this disease plays an important role in development of bladder symptoms under influence of imbalance of sex hormones. 4) Intravesical pressure was determined in patients with this disease. The urinary bladder of the younger group of patients was hyperesensitive and hypertonic, and that of the older group of patients contrarily showed a tendency of reduced tonicity. 5) Variation of the ChE activity was examined biochemically in the uriary bladder of the female mature albino rats after administration of sex hormone. The ChE activity was lowered by short-term administradon of a large dose of follicular hormone, and contrarily it was markedly elevated by long-term administration of a small dose of the same hormone. 6) In addition, variation of the ChE activity was histochemically observed in the urinary bladder albino rats treated in the same manner. Findings almost corresponded to the results obtained in the biochemical study. In other words, a marked rise of the ChE activity was demonstrated mainly in the muscular layer of the cervical and trigonal area of the urinary bladder in the group treated with a small dose of follicular hormone for a long time. 7) The MAO activity was examined histochemically in the female mature albino rats treated with various kinds of sex hormones. It increased in the group given the long-term administration of a small dose of androgen as compared with that in the control. From these results of the clinical and experimental study, it seems most probably that dysfunction of the autonomic nervous system mediates between theimbalance of sex hormones and the development of bladder symptoms in "female endocrine cystopathy".
社団法人日本泌尿器科学会の論文

女子内分泌性膀胱症に関する研究 : 特に自律神経機能異常について

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