小児尿路感染症の研究

概要

論文の詳細を見る
At the Urological Clinic of the Kyushu University Hospital, clinical observations have been made on children with the diagnosis of urinary tract infection, for the past 13 years (1954-1966). There was a statistical frequency of 20.1% in the incidence of urinary tract infection. In addition, urinary tract abnormalities, which included vesicoureteral reflux, were found to occur in a remarkably high number of cases. Urinary tract infection was felt to be pathologically significant, and, to a degree not initially anticipated. In most cases, the presenting infection was effectively eliminated with prolonged chemotherapy, but in some, surgical intervention was required as well. Because of the seemingly abnormal (high) frequency of urinary tract abnormalities in association with urinary tract infection, experimental studies with rabbits were devised which would determine any relationship between urinary tract abnormalities and renal infection. Bacterial infusion into the bladder did not result in renal infection in the unimmunized group of rabbits, despite the presence of a urinary flow disturbance. But, under essentially identical conditions, renal infection did occur in the immunized group. It is postulated that immunization facilitates the occurrence of renal infection when a urine flow disturbance is present.
社団法人日本泌尿器科学会の論文